Running thick client (.NET) in various environments - experience to share?

Hello all,

I know it is perhaps too vague question, but anyway:

Do you have experience from running a thick (preferably .NET) application in any of these modes - client installed locally, Terminal Server, Citrix ? Say, there are around 300-400 concurrent users using application.

Can you share your observations / opinions?

Thank you!
 

Dan Kutac