++ Update: August 1, 2018
The use of the InterSystems Virtual IP (VIP) address built-in to Caché database mirroring has certain limitations. In particular, it can only be used when mirror members reside the same network subnet. When multiple data centers are used, network subnets are not often “stretched” beyond the physical data center due to added network complexity (more detailed discussion here). For similar reasons, Virtual IP is often not usable when the database is hosted in the cloud.