This is how we handled that in Cache 2018 for a REST connection.

s %response.Status = $$$HTTP401UNAUTHORIZED

You can also use the .NET Gateway to call a .NET DLL.  This imports your .NET DLL into Cache and the functions are exposed as Cache Objects.

Look at %Net.Remote.ObjectGateway

You could try creating a web application on the other machine and then using a REST HTTP method to call the code to execute and return a data packet back as a %response object.  This would be similar to calling a method from an Angular UI to you server, but can be accomplished using %HTTP Requests from server A to server B as well.