Well...I don't remember using them in either Caché or the previous M/SQL and don't see them documented at all going back to Caché 4.1 (the oldest I can find on InterSystems' site), but a search of current (IRIS 2022) %SYS code suggests $zu(0) is used in database creation (ref in %SYS.DATABASE.int):

CreateDatabase+45    s rc=$zu(0,dir,blksiz,uic,0,expandby,maxfilsiz,$g(gdir,2),$
            g(gpblk),0,0,$g(ggblk),$g(freeze,1),0,$g(clmntmode,0),0,collation)

However I've also seen it like this, not in this system:

S SYS=$P($ZU(0),",",2)

Not so sure about $zu(1) but you can find it in GBLOCKCOPY.int and NLSLOAD.int.  Tried searching comp.lang.mumps?

Sure -- if you have multiple parameters for a function, the corresponding arguments can be passed by separating them by a colon (:), e.g. ZZQD "Queue1":$H-3.